Unconjugated hyperbilrubinaemia is characteristic of;
A. Rotors syndromeB. Dublin johnson syndrome
C. Chronic active hepatitis
D. Gilberts diseases
Ans. D. Gilberts syndrome
Causes of “Unconjugated” hyperbilirubenemia are
• Gilbert’s syndrome
• Criggler najar Syndrome I, Criggler najar Syndrome II
• Hemolytic anemia
• Physiological jaundice
• Hypothyroidism
• Breast milk jaundice
• Excessive RBC Destruction (Rh incompatibility, G6PD Deficency, Spherocytosis, Vitamin K,
Sulfamethaxoole)
Causes of “Conjugated” hyperbffirubenemia are:
• Parenchymal diseases (Rubella, Toxoplasmosis, CMV, Herpes infection)
• Neonatal hepatitis syndrome.
Biliary atresia (Intrahepatic/ Extrahepatic)
• Watson Alaigallie syndrome
• Choledochal cyst
• Dubin Johnson syndrome, Rotor syndrome
• Commonest cause in new born Idiopathic infantile hepatitis
