Which of the following acts as a leukotriene receptor antoagonist?
A. ZafirlukastB. Zileuton
C. Cromoglycan sodium
D. Deriphylline
Ans.
A.
The
lukasts (Zafirlukast/Montelukast) competitively antagonize cys LT1 receptor mediated
bronchoconstriction, increased vascular permeability and recruitment of
eosinophilis.
• Used for mild to moderate asthma
• Headache, rashes, eosinophilia, neuropathy
Zileuton: S-LOX inhibitor
• Short duration of action and hepatotoxic potential limit it’s use.
