Difference between a newly found test and the gold standard test | AIIMS MCQ for Medical PG Preparations .. NIME

The method used to find the difference between a newly found test and the gold standard test
A. Correlation studyb.
B. Regression study
C. Bland and altman analysis
D. Kolmogrov -Smrinov test

Ans. C. COMPARING METHODS OF CLINICAL MEASUREMENTS”

“Reporting Standards of Bland and Altman Analysis” Bland and Altman Analysis first calculates the difference in measurement values obtained by two different methods on the same subject. The mean of such differences in a sample of subjects is the “estimated bias” (difference between the methods) and the standard deviation (SD) of the differences measures the random fluctuations around the mean. If the “Limits of Agreement” (mean difference ± 2 SD) between the two methods are not clinically important.one can use the two methods interchanging.Another essential feature of the analysis is the graphical representation of the data with “Between-Method” differences (in V-axis plotted against the average (X-axis). Such a graph allows one to evaluate any relationship between the measurement of error (difference) and the assumed true value (average). Kolmogrov-Smirnov test (K.S test) is a non parametric test for the equality of continuous, one dimensional probability distributions. It is used to compare a sample with a reference probability distribution. In special cases may be used to test normality of distribution.