AIIMS MCQ :
The combination of
meclorethamine,vincristine, prednisolone, and procarbazine is used for the
treatment of patients with:
A. Acute lymphocytic leukemia
B. Chronic lymphocytic leukemia
C. Hodgkin's disease
D. Acute myelocytic leukemia
Ans. C.
·MOPP, the combination
regimen of meclorethamine, vincristine (Oncovin), prednisone,
and procarbazine, is often alternated with the ABVD regimen [doxorubicin (Adriamycin), bleomycin,
vincristine, and dacarbazine in the treatment of patients with Hodgkin's
disease, These regimens are based on the use of drugs with different mechanisms
of action and different toxicities, so that the cancer cells are attacked at
different sites of action, and the collective toxicity is not directed toward
one organ system. Mechlorethamine is
a nitrogen mustard alkylating agent, vincristine
is a mitotic spindle poison, prednisone
is a glucocorticoid with lymphotoxic
effects, and procarbazinehas
multiple actions directed against nucleic acids and proteins. Vincristine and
prednisone produce less bone marrow suppression than alkylating agents and
antimetabolites.
