Aypical antipsychotic drug | Crack AIIMS 8 May 2016 MCQs

Which of the following is not an atypical antipsychotic drug? 

A. Thioridazine 
B. Rispendone 
C. Olanzapine 
D. Clozapine

The Answer is. A. (Thioridazine)

• Atypical antipsychotics are:

o clozapine           o sulpiride              o amisuipride        o risperidone

o ziprasidone        o oianzapine         o quetiapine          o aripiprazole       o zotepine

• Acts only on the mesolimbic system but has no effect on the nigros-triatal system, has led to the development of a

heterogeneous group of drugs collectively known as atypical or newer anti psychotics.

• These are also known as second-generation antipsychotics or sero-tonin-dopamine antagonists.

• These drugs are effective antipsychotics without producing undesirable extrapyramidal side effects, i.e.,

antipsychotics without neuroleptic effect and do not cause elevation of serum prolactin levels. 

• These cause selective li,nbic dopamine blockade D4 receptors or a combination of 5-HT and weak D2 antagonist.
• These treat positive symptoms as well as negative symptoms (apathy, decreased sociality, anhedonia) of schizophrenia.