In vivo control of citric acid cycle is affected by:
B. Coenzyme A
C. ATP
D. Citrate
E. NADH
The Answer is. (C) ATP;(E) NADH
• The citric acid cycle is controlled by regulation of
selective enzymes activities — citrate synthase, isocitrate dehydrogenase,
c-ketoglutarate dehydrogenase complex.
• Regulation is by availability of ADP
•
ATP, NADH — Inhibitthe cycle
•
Acetyl CO-A
formed from pyruvate and CO-A by pyruvatedehydrogenase complex is not a part of
TCA cycle.
•
Citrate inhibits
phosphofructokinase (Glycolytic enzyme) and activates acetyl co-A carboxylase
(Fatty acid synthesis enzyme)
