Hypogonadism in cirrhosis is due to
A. Direct effect of alcohol on testesB. Increased estrogen due to decreased catabolism
C. Increased peripheral conversion of androgens into estrogen
D. Increased testosterone
E. increased progesterone levels by hepatic hyperactivity
The
Answer is. (A) Direct effect of alcohol on testes; (B)
Increased estrogen due to decreased
catabolism; (C) Increased
peripheral conversion of androgens into estrogen
•
The testicular atrophy is due to disorder of hormonal metabolism or direct
toxic effect on testis.
• In cirrhosis of liver a combined testicular and pituitary abnormality leads to decreased testosterone production. The decreased testo sterone (i.e. androgen insufficiency) production most likely result from inhibition of LH secretion by estrogens in patients with chronic liver disease
• In cirrhosis of liver a combined testicular and pituitary abnormality leads to decreased testosterone production. The decreased testo sterone (i.e. androgen insufficiency) production most likely result from inhibition of LH secretion by estrogens in patients with chronic liver disease
• Theincreased estrogen production result
from impaired hepatic metabolism and increased extraglandular conversion to
estrone and estradiol
