In vivo control of citric acid cycle is affected by:
A. Acetyl CoAB. Coenzyme A
C. ATP
D. Citrate
E. NADH
The Answer is. (C) ATP; (E) NADH • The citric acid cycle is controlled by regulation of selective enzymes activities — citrate synthase, isocitrate dehydrogenase, c-ketoglutarate dehydrogenase complex.
• Regulation is by availability of ADP
• ATP, NADH — Inhibitthe cycle• Acetyl CO-A formed from pyruvate and CO-A by pyruvatedehydrogenase complex is not a part of TCA cycle.
• Citrate inhibits phosphofructokinase (Glycolytic enzyme) and activates acetyl co-A carboxylase (Fatty acid synthesis enzyme)
