Which is true regarding benzodiazepines
A. GABA agonistB. Diazepam isa short acting benzodiazepine
C. Diazepam causes lesser respiratory depression
D. Nitrazepam is metabolized in liver
E. Diazepam has higher abuse potential than Midazolam
The Answer
is. (C) Diazepam causes lesser respiratory depression (D) Nitrazepam
is metabolized in liver
•Benzodiazepines act on BZD receptors of GABA-BZD receptor-chloride channel complex, modulates BID receptors, increases the frequency of Cl Channel opening induced by submaximal concentration of GABA. Thus it is not GABA agonist, it is GABA facilitatory but no mimetic action
•Benzodiazepines act on BZD receptors of GABA-BZD receptor-chloride channel complex, modulates BID receptors, increases the frequency of Cl Channel opening induced by submaximal concentration of GABA. Thus it is not GABA agonist, it is GABA facilitatory but no mimetic action
• Coma, respiratory depression though rare, can occur
with ultra short acting agents-Like Midazolam, Triazolam
• The dependence producing liability of BZDs is low.
They are rarely used
• Agents that are absorbed rapidly and are lipid
soluble such as diazepam, have rapid onset of action and higher abuse potential
• Midazolam; extremely rapid absorption ; more liable
for abuse
• Diazepam has rapid onset of action
• Benzodiazepines are metabolised in liver by
dealkylation and hydroxylation
Note: Diazepam undergoes entero hepatic circulation
