True about Glutathione reductase
A. Sulphur containing enzymeB. Important in methemoglobinemia
C. Free radical scavenger
D. essential for coversion of retinol to retinal
E. All
The Answer is. (C) Free radical scavenger
• Glutathione reductase, a flavo protein enzyme
containing FAD catalyzes oxidised glutathione to reduced glutathione.
• Glutathione reductase (GR) also known as
glutathione-disulfide reductase (GSR) is an enzyme that in humans is encoded by
the GSR gene
• The glutathione reductase is conserved between all
kingdoms. In bacteria, yeasts, and animals, one glutathione reductase gene is
found; however, in plant genomes, two GR genes are encoded
• Glutathione plays a key role in maintaining proper
function and preventing oxidative stress in human cells. It can act as a
scavenger for hydroxyl radicals, singlet oxygen, and various electrophiles.
• It plays a key role in the metabolism and clearance of
xenobiotics, acts as a cofactor in ceratin detoxifying enzymes, participates in
transport, and regenerates antioxidants such and Vitamins E and C to their
reactive forms.
