Drugs causing malformation in the fetus | Crack PGIMER 22 MAY 2016

Drugs which cause malformation in the fetus include 

A. Heparin 
B. Warfarin 
C. Valproic acid 
D. Steroids 
E. Phenytoin

The Answer is. (B) Warfarin; (C) Valproic acid; (D) Steroids; (E) Phenytoin

• Heparin doesn’t cross placental barrier.

• Drugs with fetal malformations are:

— Phenytion —* ‘Fetal hydantoin syndrome’ hypoplastic phalanges, cleft lip, cleft palate, microcephaly
— Valproic acid — Neural tube defect, spina bifida

— Warfarin — ‘Chondrodysplasia punctata’ — Craniofacial abnormality

— Steroids — Maternal and Fetal adrenal hypoplasia, cleft palate/lip, cardiac defects