Thursday, 7 April 2016

Transfer (t) RNAs | Crack PGIMER 22 MAY 2016

Which of the following statements is true of all transfer (t) RNAs?

a. The 3′ end is phosphorylated
b. They are duplex chains
c. No methylated bases are found
d. The 3′ end base sequence is CCA

The answer is d.
For transfer RNAs, the 5′ end is often guanosine and is always phosphorylated, while the 3′ end is CCA. Although transfer (t) RNA molecules have many features in common, the primary feature that sets them apart is their specificity for different amino acids and the corresponding specific differences of their anticodons. Each tRNA is an L-shaped single chain composed of up to 93 ribonucleotides. Each contains up to 15 methylated bases, and about half of the nucleotides are base-paired into double helices. Activated amino acids attach to the terminal 3′-hydroxyl group of the adenosine