Slow-reacting substances of anaphylaxis are derived from
A.arachidonic acid through the cyclooxygenase pathway.
B.arachidonic acid through the lipoxygenase pathway.
C. alternate complement pathway
D. classical complement pathway
The
answer is B.
Mediators of inflammation and vasoactive substances are produced from arachidonic acid through either the
cyclooxygenase or the lipoxygenase pathway. Leukotrienes C4, D4, and E4, which
are known as slow-reacting substances of anaphylaxis (SRS-As), are synthesized
through the lipoxygenase pathway. The cyclooxygenase pathway results in the
formation of prostaglandins and thromboxanes,
