Statements about hairy cell | PGI Nov 2017 Preparations MCQ

All of the statements about hairy cell are true except: 

A.Massive lympadenopathy
B. Result from an expansion of neoplastic B lymphocytes
C. Cells are positive for tartarate resistant acid phosphate (TRAP) 
D. The cells express CD 5 consistently
E. Lukemia cells look like broken hair ends

Answer. A.Massive lympadenopathy; (D) The cells express CD5 consistently; (E) Lukemia cells look like broken hair ends

Hairy Cell Leukemia

·        Appearance of leukemia cells-fine hairlike projection

·        Hairy cell rearrange and express immunoglobulin genes which firmly assign them to B cell lineage

·        Characteristic-presence of tartrate resistant acid phosphatase (TRAP)

·        Involve mainly older male

·        Splenomegaly (massive)

·        Hepatomegaly not marked

·        Lymphadenopathy rare

·        Pancytopenia in 50% cases

·        Splenectomy is of benefit

·        Alpha interferon has proved to be effective

·        Hairy cells usually express the pan B-cell markers CD19 & CD20 and some times monocyte associated antigen CD11c, CD25, CD103