Use of timolol in the eye can cause | PGI Nov 2017 Preparations MCQ

Use of timolol in the eye can cause: 

A. AV block 
B. Bradycardia 
C. Hypertension 
D. Hypotension 
E. Asthma

Answer. A. AV block; (B) Bradycardia; (D) Hypotension; (E) Asthma .

On topical application of β-blocker on eye, there can occur significant systemic absorption, producing systemic adverse effects :

• Bronchospasm

• Accentuation of heart block

• Congestive heart failure especially in elderly

• Bradycardia

• Other adverse effects: depression, anxiety, confusion, drowsiness, loss of libido, skin rashes, diarrhoea, nausea.