CAD predisposing factors
A. HomocysteinemiaB. ↓ L Lipoprotein B
C. ↓ Fibrinogen
D. ↓ HDL
E. ↓ plasminogen activator inhibitors 1
Answer. A.
Homocystenimia ; (B) ↓ Fibrinogen; (E) ↓ Plasminagen activator
• LDL also called β-lipoprotein is most
directly related to CAD.
• HDL also called α-lipoprotein is
inversely related to CAD.
• VLDL also called prebeta is
associated with premature atherosclerosis. It is strongly associated with
peripheral vascular disease
(Intermittent claudication)
• Plasminogen activator inhibitor -1
causes
— Venous thrombosis
— Tail vein thrombosis
— Hind, foot oedema :
• Certain genotypes of PAT-I gene
appear to co-related with increased coronary risk.
• Homocysteinemia is associated with
coronary artery disease.
• Several makers of hemostatic and
thrombotic function in addition to homocysteine level characteristics
event such as MI and stroke
— The markers are
level of plasminogen activator inhibitor-i,
— Plasma fibrinogen.
— C—Reactive protein
• Infection causing coronary heart
disease and atherosclerosis
— Herpes
— Cytomegalo virus
— Chlamydia pneumonia;
