Drug clinically interacting with ribosomes to interfere with translation in bacteria
A. TetracyclineB. Erythromycin
C. Puromycin
D. Oligomycin
E. None
. Answer. A. Teracycline ; (B) Erythromycin :
• The process of translation is divided into
:
— Initiation
— Elongation
— Termination.
, Streptomycin binds to the 30 S
sub-units and distorts its structure, interfering with the initiation of protein synthesis.
• Tetracyclines interact with small
ribosomal sub-units blocking access of the amino-acyl t-RNA to the m-RNA
ribosome complex.
• Puromycin, chloramphenicol inhibits
elongation.
• Clindamycin Erythromycin bind irreversibly to a site of 50S submit of the
bacterial ribosome and inhibit translation.
Though puromycin inhibits translation , it does not interfere with ribosomes
