Trans-placental spread is least with?
A. HBVB. Rubella
C. HSV
D. HIV
E. None of the above
Answer. C. HSV.
“The acquisition of genital herpes during
pregnancy is associated with spontaneous abortion, prematurity, and congenital
and neonatal herpes. A recent cohort study of pregnant women without evidence
of previous herpes infection demonstrated that ~2% of the women acquired a new
herpes infection during the pregnancy. Approximately 60% of the newly infected
women had no clinical symptoms. Infection occurred equally in all three
trimesters. If herpes seroconversion occurred early in pregnancy, the risk of
transmission to the newborn was very low. In women who acquired genital herpes
shortly before delivery, the risk of transmission was high. The risk of active
genital herpes lesions at term can be reduced by prescribing acyclovir for the
last 4 weeks of pregnancy to women who have had their first episode of genital
herpes during the pregnancy.
Herpesvirus infection in the newborn can be
devastating. Disseminated neonatal herpes carries with it high mortality and
morbidity rates from CNS involvement. It is recommended that pregnant women
with active genital herpes lesions at the time of presentation in labor be
delivered by cesarean section