True about nitric oxide is all except
A. Free radical
B. Vasodilator
C. Oxidizing agent
D. Catalyst
E. Platelet aggregator
. Answer. E. Platelet aggregator.
• Nitric oxide is a gas synthesized by
endothelial cells previously known as endothelial derived relaxing
Factor (EDRF), causes vasodilatation.
It stimulates guanyl cyclase.
•NO
has very short half life (3-4 sec.) as in tissues it reacts with oxygen and
superoxide producing peroxynitrite which decomposes to form highly reactive 0H radical.
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Importances
of Nitric oxide
• Vasodilator, important
in regulation of BP
• Involved inn penile
erection.
• Neurotransmitter in
brain and peripheral autonomic nervous system.
• Role in long- term potentiation.
• Role in neurotoxicity
• Low level of NO
involved in causation of pyloric spasm in infantile hypertrophic pyloric
stenosis.
• May have role in
relaxation of skeletal muscle.
• May constitute part of
primitive immune system
• Inhibitis adhesion,
activation, and aggregation of platelets.
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