Finasteride acts by:
A. a-BlockadeB. 5α reductase Inhibition
C. Androgen Receptor blockade
D. α-blockade
Ans. B.
Finasteride inhibits 5 α reductase and hence reduces the circulating and prostatic Dihydrotestosterone concentration. Dihydrotestosterone is more active than testosterone. It s sites of action include prostate gland, hair follicles.
Uses of finasteride: decreases prostate size after prolonged use and thus helpful in relieving the’ static component of obstruction.
Other uses include - male pattern baldness (early stages); Hirsuitism in women
S/E: decreased libido, impotence, decreased volume of ejaculate
Androgen Receptor Inhibitors:
Cyperoterone: Used in hirsuitism in women and in cases of precocious puberty and inappropriate sexual drive in men
• Also (-) any feed back increase in LH, FSH.
Flutamide: Used in prostatic carcinoma.Bicalutamide,
Niclutamide - Orally active; Used in metastatic prostatic CA.Finasteride inhibits 5 α reductase and hence reduces the circulating and prostatic Dihydrotestosterone concentration. Dihydrotestosterone is more active than testosterone. It s sites of action include prostate gland, hair follicles.
Uses of finasteride: decreases prostate size after prolonged use and thus helpful in relieving the’ static component of obstruction.
Other uses include - male pattern baldness (early stages); Hirsuitism in women
S/E: decreased libido, impotence, decreased volume of ejaculate
Androgen Receptor Inhibitors:
Cyperoterone: Used in hirsuitism in women and in cases of precocious puberty and inappropriate sexual drive in men
• Also (-) any feed back increase in LH, FSH.
