Greatest stimulator for ADH secretion | PGIMER MCQs for MD MS Preparations

Greatest stimulator for ADH secretion 

a. Hyperosmolarity 
b. Hyponatremia 
c. Hypotension 
d. Hypovolemia 
e. Hypokalemia

Ans : (A) Hyper osmolarity ;

Regulation of ADH secretion

Increase ADH                        Decrease ADH

↑Plasma osmolarity            -Low plasma osmolarity

↓BP

Drugs

Morphine                               Alcohol

Cyclophosphamide              Clonidine

• Osmotic regulations cause ADH secretion as high as 20 times the normal, while hypovolemia (15- 25% decrease) cause as high as 50 times normal