Hepatotoxic Inhalational Anesthetic

Which of the following inhalational anesthetic is hepatotoxic: 

A. Halothane 
B. Enfluorane 
C. Ether 
D. Sevofluorane

Ans. A.  Halothane 

• Halothane and other halogenated inhalational anesthetic agents, such as enflurane, isoflurane, sevoflurane, and desfiurane, are known to cause severe liver dysfunction. 

• When the World Health Organization WHO.  drug monitoring database was reviewed for the medications that most commonly cause fatal hepatotoxicity; halothane was one of the 10 most common causes. 

• Two major types of hepatotoxicity are associated with halothane administration. The two forms appear to be unrelated and are termed.