8-month boy baby is evaluated because of repeated episodes of pneumococcal pneumonia. Serum studies demonstrate very low levels of 1gM, IgG, and IgA. This is related to a deficiency of which of the following?
A. Adenosine deaminaseB. Class III MHC gene
C. Gamma chain of the IL-2 receptor
D. Tyrosine kinase
Ans.D. Tyrosine kinase
As
the history is of recurrent infections with bacteria pneumococcal pneumonia. ,
it indicates primary humoral immunodeficiency. As this is occurring in an
8-month old male child, it indicates X-linked agammaglobulinemia also called as
Burton’s
agammaglobulinemia. In this disorder there is deficiency of the enzyme
tyrosine kinase, which is required for B cell maturation
