True about protooncogene:
a. Important for normal cell growthb. Oncogenesis
c. C-myc overexpression causes lymphoma
d. Mutation causes RB
e. Deletion cause Sickle cell disease
Ans. (A) Important for normal cell growth; (B) Oncogenesis;
(D) Mutation causes RB
* Protooncogenes are important for cellular function related
to growth and proliferation.
* C-Myc tranlocation causes Burkitt’s lymphoma.
* Transcription of RB causes Retioblastoma. Rb gene is a
tumour supression gene, mutation of it cause Retinoblastoma (RB).
