Neonatal thymectomy leads to
A. Depletion of lymph nodesB. Depletion of para cortical areas of the lymph node
C. increased IgM level
D. Increased production of lymphocytes by the bone narrow
Ans.
B. [Depletion of paracortical area of
the lymph nodes]
• The primary function of the thymus is the
production of the thymic lymphocytes, if is the major site for lymphocyte
proliferation in the body.
•
The importance of the thymus in lymphocytes proliferation and development of
CMI is evident from the lymphopenia, deficient graft rejection and so called
"runt disease" seen in neonatallythymectomized mice, Deficient CMI is
also seen in congenital aplasia of the thymus in human beings Di George
syndrome and in mice 'nude mice'.
Lymphoid follicles are usually present but lymph node paracortical area
and thymus - Dependent regions of spleen show variable degrees of depletion
