Monday 11 January 2016

The two nitrogen atoms in urea


The two nitrogen atoms in urea arise from: 

A. Ammonia and glutamine 
B. Ammonia and aspartic acid
C. Glutamine and glutamic add
D. Glutamine and alanine


 Ans. B. Ammonia and Aspartic acid
Urea cycle
• Takes place in liver and brain.
• 1st two reactions occur in mitochondria.
• 1st two reactions are rate controlling reactions.
• Nitrogen atoms arise from Ammonia and Aspartic acid
• Combination of “Hyperammonemia+ increased Blood Glutamine +Blood urea” suggests defect in Urea Cycle. Lethargy, vomiting, coma are associated