ACE inhibitor induced cough is mediated by.
A. Bradykinin
B. Substance - P
C. Prostaglandin
D. Serotonin
E. Renin
A. Bradykinin
B. Substance - P
C. Prostaglandin
D. Serotonin
E. Renin
Ans. A. Bradykinin ; (B)
Substance—P ; (C) Prostaglandin
•About 5-20% of patients taking ACE inhibitors develop a non-productive
cough. Onset is usually within
1 week of starting the drug but can be delayed up to 6 months. Mechanism is not
known with certainty, but may be due to accumulation
of bradykinin, substance-P, and / or prostaglandin which are degraded by
ACE.
• Treatment:Cough disappears within 4
days if stoppage. Sometime require cessation of therapy.
• Thromboxane antagonism reduces ACE inhibitor induced cough.
