Cells in intestine that migrate to surface include the following EXCEPT:
B. Enterocytes
C. Goblet cells
D. . Enteroendocrine cells
Ans.
A. Paneth cells.
• They are found only in deeper part of
the intestinal crypts ofLieberkuhn.
• Unlike other lineages, Paneth cells
migrate to the crypt base.
• They have a long life-span of —28
days.
• Paneth cells are noted for their
prominent secretory apparatus.
• Granules are readily visulaized using
a variety of stains including the Phloxine-Tartrazine histochemical stain.
• They are very rich in ZINC.
• Paneth cells provide host defense
against microbes in the small intestine
• They are known to produce lysozyme,
which destroys bacteria. They are also known to secrete defensins.
• In addition to defensins, Paneth
cells secrete lysozyme and phospholipase A2, both of which have clear
antimicrobial activity. This battery of secretory molecules gives Paneth cells
a potent arsenal against a broad spectrum of agents, including bacteria, fungi
and even some enveloped viruses.
