Enzymes regulated by CAMP dependent Phosphorylation | PGI Frequently Asked Medical PG topics

Which of the following enzymes are regulated by CAMP dependent phosphorylation?

A. Citrate lyase 
B. Phosphorylase b 
C. Pyruvate dehydrogenase 
D. Glycogen synthase 
E. Ligase

Ans. A. Citrate lyase ; (B) Phosphorylase b ; (C) Pyruvate dehydrogenase; (D) Glycogen synthase;

• Phosphorylation activates:
- Glycogen phosphorylase
- Citrate lyase
- Phosphorylase b kinase
- HMG CoA reductase kinase
• Dephosphorylation activates:
- Acetyl coA carboxylase
- Glycogen synthase
- Pyruvate dehydrogenase

- Valine, isoleucine & Methionine metabolism & oddchain FA metabolism (Propionyl CoA)
- Phenylalanine & Tyrosine metabolism (Fumerate)
- Aspertate (Oxaloacetate)
- Glutamate (α-Ketoglutarate)

- HMG CoA reductase
- Pyruvate kinase and PFK-2.
• Other enzymes regulated by cAMP dependent Phosphorlation:
- Hormone sensitive lipase
- Fructose 2,6 biphosphatase/PFK-2
- Tyrosine hydroxylase
- Histone H1, H,B
- Cardiac phospholamban
- Protein phosphatase 1-inhibitor-I