True about Autoimmune type-II Liver disease
A. Antinuclear antibody
B. LKM-1 antibody
C. Anti smooth muscle antibody
D. Ds DNA
E. LC-1, & LC-2
A. Antinuclear antibody
B. LKM-1 antibody
C. Anti smooth muscle antibody
D. Ds DNA
E. LC-1, & LC-2
Ans. B. LKM-1 antibody
;(E) LC-1, LC-2.
Depending
upon the present of antibody in serum, autoimmune hepatitis is of 3
types:-
(1) AIH type I — It is characterised by ANA with or without SMA.
• It is the most common autoimmune hepatitis.
(2) AIH type II — Characterised by anti p 450 and anti UGT autoimmunity.
• LKM-l antibody against — P4502D6 is found.
• This type most commonly leads to fulminant hepatitis.
• Low IgA level also common.
• Common in paediatrics age group.
• Anti LC-1 (Liver cytosol-1) and LC-2 along with LKM-1 found.
(3) AIHtype-III is characterised by absence of ANA, SMA, and LKM-1 and anti SLA/L.P, and ASGPR (asialoglycoprotein receptor) is present.
• Long time result is most important for liver transplantation in type-2.
(1) AIH type I — It is characterised by ANA with or without SMA.
• It is the most common autoimmune hepatitis.
(2) AIH type II — Characterised by anti p 450 and anti UGT autoimmunity.
• LKM-l antibody against — P4502D6 is found.
• This type most commonly leads to fulminant hepatitis.
• Low IgA level also common.
• Common in paediatrics age group.
• Anti LC-1 (Liver cytosol-1) and LC-2 along with LKM-1 found.
(3) AIHtype-III is characterised by absence of ANA, SMA, and LKM-1 and anti SLA/L.P, and ASGPR (asialoglycoprotein receptor) is present.
• Long time result is most important for liver transplantation in type-2.
