Treatment of DI
A. ADH
B. Thiazide
C. Loop diuretics
D. Insulin
E. Chlorpromazine
A. ADH
B. Thiazide
C. Loop diuretics
D. Insulin
E. Chlorpromazine
Ans. A. ADH; (B) Thiazide
•
Desmopressin (DDAVP = desamino-D-arginine-8 vasopressin) acetate is the
treatment of choice for central diabetes insipidus. It is a synthetic analogue
of AVP that acts selectively at V2 receptors to increase urine concentration
and decrease urine flow in dose dependent manner. Lypressin or vasopressin are
alternatives.
• Other drugs for DI.
Chlorpropamide for pituitary DI
— Thiazide diuretics for Nepbrogenic DI
— Carbamazipine reduced the urine volume in pituitary DI
— Clofibrate has shown beneficial for nephrogenic DI
— Indomethacin
