Whole body radiation MCQ | PGIMER MCQs for MD MS Preparations

Whole body radiation is indicated in 

A. Advanced head & neck tumours 
B. BM transplantation 
C. Medulloblastoma 
D. Mycosis fungoides 
E. Histiocytosis-x ]

 Ans. B.  Bone marrow transplantation ; (D) Mycosis fungoides;
When radiation is given in a way to cover thewhole body it is called total body irradiation or whole body irradiation. This done for one of two reasons
(i) To suppress the pt’s immune system and prevent rejection of donor bone marrow after BM transplantation using donor BM from someone other than the patient.
(ii) To kill abnormal cells that escape other therapies such as surgeries, chemotherapy or local irradiation and remain hidden in the body to regrow later.
• It is used in:
- Aplastic anaemia to prevent rejection of donor marrow.
- Beta thalassernia
- CML
-AML&ALL
-NHL
- Neuroblastoma
- Ewing’s sarcoma I unfavourable pediatric sarcoma
• Mycosis fungoides is treated with whole body radiation.
• Histiocytosis X resolves spontaneously in usual cases and it can be treatedwith Chemotherapy.
•Medulloblastoma can be treated with craniospinal radiation.
• Advanced head & neck turnours are treated with local or regional radio therapy.