In leucocyte adhesion deficiency Type II, the defect is in the synthesis of:
A. Fucosyl transferase
B. β2-integrins C. NADPH oxidase
D. Leukotrienes
Ans. A. Fucosyl transferase
Table: Defects in
leukocyte functions
Disease
|
Defect
|
Genetic
|
|
Leukocyte adhesion deficiency 1
|
Beta chain of CD11/CD18 integrins
|
Leukocyte adhesion deficiency 2
|
Fucosyl transferase required for synthesis of
silylated oligosaccharide receptor for selectin.
|
Chronic granulomatous disease
|
Decreased oxidative burst
|
X-linked
|
NADPH oxidase membrane component.
|