Wednesday, 9 December 2015

Medical PG Preparations | Leucocyte adhesion deficiency Type II


In leucocyte adhesion deficiency Type II, the defect is in the synthesis of: 

A. Fucosyl transferase 
B. β2-integrins 
C. NADPH oxidase 
D. Leukotrienes

Ans. A.  Fucosyl transferase
Table: Defects in leukocyte functions

Disease
Defect
Genetic

Leukocyte adhesion deficiency 1
Beta chain of CD11/CD18 integrins
Leukocyte adhesion deficiency 2
Fucosyl transferase required for synthesis of silylated oligosaccharide receptor for selectin.
Chronic granulomatous disease
Decreased oxidative burst
X-linked
NADPH oxidase membrane component.