Tuesday, 15 December 2015

State Medical PG Entrance | Regarding Lamotrigine,


Regarding Lamotrigine, which of the following is a TRUE statement? 

A. It is a dopaminergic agonist used in Parkinsonism 
B. It acts by blocking NMDA type of glutamate receptors 
C. It is a broad spectrum antiepileptic drug 
D. It suppresses tonic-clonic seizures but worsens absence seizures

Ans. C. It is a broad spectrum antiepileptic drug
•Lamotrigine is useful for the treatment of various types of seizures including GTCS, absence seizures and myoclonic epilepsy.
•Lamotrigine acts by blocking Na+ channels, T-type Ca2+ channels and by increasing GABAergic activity.

•Major adverse effect of lamotrigine is Steven Johnson syndrome and toxic epidermal necrolysis.