Regarding Lamotrigine, which of the following is a TRUE statement?
A. It is a dopaminergic agonist used in Parkinsonism
B. It acts by blocking NMDA type of glutamate receptors C. It is a broad spectrum antiepileptic drug
D. It suppresses tonic-clonic seizures but worsens absence seizures
Ans. C. It is a broad spectrum antiepileptic drug
•Lamotrigine
is useful for the treatment of various types of seizures including GTCS,
absence seizures and myoclonic epilepsy.
•Lamotrigine
acts by blocking Na+ channels, T-type Ca2+ channels and by increasing GABAergic
activity.
•Major
adverse effect of lamotrigine is Steven Johnson syndrome and toxic epidermal
necrolysis.
