Strong correlation with colorectal cancer is seen in
A. Peutz-Jeghers’ polyp
B. Familial polyposis coli
C. Juvenile polyposis
D. Hyperplastic polyp
A. Peutz-Jeghers’ polyp
B. Familial polyposis coli
C. Juvenile polyposis
D. Hyperplastic polyp
Ans. B. Familial polyposis coil
• The incidence of FAP is estimated to
be 1 in 6000 to 1 in 13 000: It was estimated that more than 50,000 families in
the United States could benefit from genetic counseling for this disorder.
Affected individuals carry germ line mutations of the APC gene on chromosome 5q2 1 -q22.
•
Individuals with mutations in APC have
multiple colonic adenomas and, if untreated, will inevitably develop CRC.
