Raised AFP | PGI Frequently Asked Medical PG topics

Raised AFP is seen in 
A. PCKD 
B. Cystic hygroma 
C. Gastroschisis 
D. Chromosomal trisomies 
E. Hepatitis

Ans. A. PCKD ; (B) Cystic hygroma ; (C) Gastroschisis; E. Hepatitis:

• AFPis higher than normal in
— Liver and germ cell tumour                           — Recent or impending fetal demise
— Gastroschisis                                                   --- Fetal renal damage
— Cirrhosis, hepatitis
* In chromosal trisomies, its value is decreased.

• Extremely high level of AFP is specific for fetal congenital anomalies like meningomyelocele, PCKD, cystic hygroma and Gastroschisis