In a family, the father has widely spaced eyes, increased facial hair
and deafness. One of the three children has deafness with similar facial
features. The mother is normal. Most likely pattern of inheritance in
this case is
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X-linked recessive
Ans. A. Autosomal dominant
Here father is affected and one of three children is affected. Mother is normal. It is not clear whether male or
female child is affected.
• Autosomal dominant disorders: Any child has 50% chances of inheriting the disease.
• It cannot be Autosomal recessive disorder as here both father and children are affected. And homozygous father and normal mother will have asymptomatic children carrier.
• X-linked dominant disorder: Affected father will not affect male child. It affects only daughter.
• X-lirilced recessive disorder: Affected father will not affect male child. Female child will be affected only if mother is also carrier.
* Therefore most likely Answer is autosomal dominant disorder
A. Autosomal dominant
B. Autosomal recessive
C. X-linked dominant
D. X-linked recessive
Ans. A. Autosomal dominant
Here father is affected and one of three children is affected. Mother is normal. It is not clear whether male or
female child is affected.
• Autosomal dominant disorders: Any child has 50% chances of inheriting the disease.
• It cannot be Autosomal recessive disorder as here both father and children are affected. And homozygous father and normal mother will have asymptomatic children carrier.
• X-linked dominant disorder: Affected father will not affect male child. It affects only daughter.
• X-lirilced recessive disorder: Affected father will not affect male child. Female child will be affected only if mother is also carrier.
* Therefore most likely Answer is autosomal dominant disorder
