Monday, 26 October 2015

Pancreatic Ca | PGI Frequently Asked Medical PG topics

True about pancreatic Ca 
A. M.C. symptom is pain 
B. Ca head of pancreas causes obstruction of both pancreatic and billiary duct 
C. Smoking predisposes
D. Long term DM is a potent risk factor.
E. Family H/O familial adenomatous polyposis syndrome


Ans. A. M.C. Symptom is pain; (B) Ca head of pancreas causes obstruction of both pancreatic and billary duct; (C) Smoking predisposes; D. Long term DM  is a potent risk factor.

• Pancreatic cancer has the following risk factors:-
Male Sex 
Blacks > whites 
Age>50 yrs. 
—Cigarette smoking Most consistent risk factor. Whether due to direct carcinogenic effect of tobacco metabolites on the pancreas or an as yet undefined exposure that occurs more frequently in cigarette smokers is uncertain.
Chronic pancreatitis 
Long standing DM 
Obesity 
Mutation in k-ras gene and pio4 
• Alcohol abuse or cholelithiasis are not risk factors nor is it associated with coffee consumption. 
• In Familial adenomatous polyposi,s (FAP), polyps are found in large intestine and is not a/w any other malignancies.