Dietery factors associated with colon carcinoma

Dietery factors associated with colon carcinoma 
A. High fiber 
B. Low fiber 
C. Smoked fish 
D. High fat intake 
E. Japanese are common to develop Ca colon

Ans. B. Low fiber ; (C) Smoked fish; (D) High fat intake ; (E) Japanese are common to develop Ca colon :

Dietary risk factors for colorectal Ca, 

— Diet rich in fat and red meat -                           — low fiber diet. 

• Colorectal Ca has increased in Japan since that ration has adopted a more western diet. 

• Animal Fats : Ingestion of animal fats — increased proportion of anaerobes in the gut microflora which leads to conversion of normal bile acids to carcinogens. This provocative hypothesis is supported by several reports of increased amounts of fecal anaerobes in the stools of pts of colonic Ca. 

• Some studies suggest that certain elements of the diet protect against the development of neoplasia. 

Selenium, dithiothiones, thioester’s, terpenes and carotenoids might act as anticarcinogensby reducing free oxygen radicals in the colon at the muscosal surface, 

• Fiber:-An increase in dietary fiber may lower the incidence of Ca in pts who have a high fat diet. 

Dietary fiber —increases the intestinal transit time — Reduction of the exposure of colonic mucosa to potential carcinogen and dilution of these carcinogens because of enhanced fecal bulk. 

• The role of fiber in colorectal Ca is controversial. Because, a diet low in fiber can lead to chronic constipation and diverticulosis. If a low-fiber diet were a significant risk factor in colorectal Ca, individuals with diverticulosis should be at higher risk for developing colorectal Ca ; This is not the case. 

• According to the National Research Council, interim guidelines for diet recommendation for prevention of colorectal Ca are 

—Fat in the diet from 40-30% of total caories, 

— increased consumption of fiber containing foods. 

—* Limit salt-cured, smoked foods. 

—* Limit food additives show to be potential carcinogens, 

 — Establish research protocals for direction of mutagen in foods. 

— Limit alcohol consumption.