Drugs used for ovulation induction
A. Clomiphene citrate
B. Danazol
C. Cyproterone acetate
D. Tamoxifen
E. Mefenemic Acid
Ans. (A) Clomiphene citrate ; (D) Tamoxifen
• The following drugs are used either single or in combination for induction of ovulation
— Stimulation of ovulation
• Clomiphene citrate (CC)
•FSH
•HCG
•GnRH
• GnRH analogues
— Reduction of level of:
• Androgen = Dexamethasone
• Prolactin = Bromocriptine
— Substitution therapy
•Hypothyroidism — Thyroid extract
•Diabetes mellitus Antidiabetic drugs.
• Tamoxifen is an anti-oestrogen, can be used where the patient is intolerant to clomiphene.
• Cyclofenil is a compound structurally similar to diethyl stilbestrol. It has got anti-oestrogenic property and it produces abundant thin, elastic cervical mucous which facilitate sperm penetration. The indications are same as that of clomiphene.
• Cyproterone acetate is an anti-androgenic progestogen. The compound blocks the hormone action at the receptorlevel. It decreases 5c reductase activity of reduces LH secretion.
It is used in idiopathic hirsutism or hyperandrogenic state.
A. Clomiphene citrate
B. Danazol
C. Cyproterone acetate
D. Tamoxifen
E. Mefenemic Acid
Ans. (A) Clomiphene citrate ; (D) Tamoxifen
• The following drugs are used either single or in combination for induction of ovulation
— Stimulation of ovulation
• Clomiphene citrate (CC)
•FSH
•HCG
•GnRH
• GnRH analogues
— Reduction of level of:
• Androgen = Dexamethasone
• Prolactin = Bromocriptine
— Substitution therapy
•Hypothyroidism — Thyroid extract
•Diabetes mellitus Antidiabetic drugs.
• Tamoxifen is an anti-oestrogen, can be used where the patient is intolerant to clomiphene.
• Cyclofenil is a compound structurally similar to diethyl stilbestrol. It has got anti-oestrogenic property and it produces abundant thin, elastic cervical mucous which facilitate sperm penetration. The indications are same as that of clomiphene.
• Cyproterone acetate is an anti-androgenic progestogen. The compound blocks the hormone action at the receptorlevel. It decreases 5c reductase activity of reduces LH secretion.
It is used in idiopathic hirsutism or hyperandrogenic state.
