In pemphigus vulgaris, antibodies are present against | AIIMS MCQ for MD MS, Medical PG Coaching and Preparations .. NIME

In pemphigus vulgaris, antibodies are present against:
A. Basement membrane
B. Intercellular substance
C. Cell nucleus
D. Keratin

Ans. B.

In Pemphigus antibodies are directed against desmoglein (a trans membrane desmosomal glycoprotein belonging to cadherin-a calcium dependent adhesion molecule) in intercellular substance causing loss of cohesion between epidermal cells (of st.basale layer) lead to formation of acantholytic cells which can be seen on Tzank smear.