Hephaestin, a molecule, which mediates iron absorption from intestine is supposed to be a?
A. DMTB. Ferreductase
C. Ferroxidase
D. Ferrochelatase
Ans.
C. Ferroxidase.
- Hephaestin plays an important role in
intestinal iron absorption and is predicted to be a ferroxidase based on
significant sequence identity to the serum multi copper
ferroxidaseceruloplasmin.
- It has both amine oxidase and
ferroxidase activity in cultured cells and primary intestinal enterocytes.
-The specificity of its activity can be
shown by immunoblotting, immunoprecipitation, and immunodepletion experiments.
- By way of its ferroxidase activity,
it facilitates iron export from intestinal enterocytes, most likely in
cooperation with the basolateral iron transporter, Iregi.
