Necrosis in Anoxia of liver | PGI MCQs for MD MS Preparations

In anoxia of liver, necrosis is seen in: 

A. Centrilobular 
B. Around the periphery 
C. Around the central vein 
D. Around the bile duct
E. around the central artery

Ans. C. Around the central vein: 

• The histological hallmark of ischemic hepatitis or shock1iver is zone three necrosis. 

• Depending upon the degree of ischemia, a variable degree of architectual collapse around the central vein may occur with severe and prolonged ischemia. Necrosis may extended to the midzonal hepatocytes.

Note: Functions of different zone of liver.

Zone 1 — Glycogen synthesis and glycogenolysis inhibitor-I: 

— Main area for protein metabolism 

— Formation of plasma protein 

— Conjugation of certain drugs. 

Zone 3 —* Glycogen storage 

Lipid and pigment formation metabolism of certain drugs and chemicals.

Zone 2 -4- Share functions of both zones.