Saturday, 21 November 2015

Necrosis in Anoxia of liver | PGI MCQs for MD MS Preparations

In anoxia of liver, necrosis is seen in: 

A. Centrilobular 
B. Around the periphery 
C. Around the central vein 
D. Around the bile duct
E. around the central artery


Ans. C. Around the central vein: 
• The histological hallmark of ischemic hepatitis or shock1iver is zone three necrosis. 
• Depending upon the degree of ischemia, a variable degree of architectual collapse around the central vein may occur with severe and prolonged ischemia. Necrosis may extended to the midzonal hepatocytes.

Note: Functions of different zone of liver.
Zone 1 — Glycogen synthesis and glycogenolysis inhibitor-I: 
— Main area for protein metabolism 
— Formation of plasma protein 
— Conjugation of certain drugs. 
Zone 3 —* Glycogen storage 
Lipid and pigment formation metabolism of certain drugs and chemicals.
Zone 2 -4- Share functions of both zones.