Genodermal disease | PGI MCQ for Medical PG Coaching & Preparations .. NIME

Genodermal disease that can cause skin malignancy are
A. Xeroderma pigmentosa
B. Neurofibromatosis
C. Actinic keratosis
D. Porphyria cutanea tarda
E. None of the above.


Ans. (A) Xeroderma pigmentosa;
• Xeroederama pigmentosa is a rare autosomal recessive neurocutaneous disorder in addition to
skin lesions, patients may show:-
- Progressive mental deterioration, microcephaly, ataxia, peripheral neuropathy, spasticity,
choreoathetosis, Hypogonadism and nerve deafness.
• Inheritable conditions a/w skin cancer
- Albinism
- Xeroderma pigmentosum
- Congenital nevus.
- BCC nevus syndrome
• Actinic keratosis is a premalignant skin lesion.
• Neurofibromatosis can undergo malignant changes to sarcoma & CNS tumours.