NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. CT
C. PT
D. APTT
Ans. A.
Aspirin - It acetylates and inhibits the enzyme cyclooxygenase & TX synthetase - inaätivating them irrevessibly. The platelets are exposed to aspirin in portal circulation before it gets deacetylated in the liver and hence t BT.
Causes of ↑BT- any qualitative or quantitative defect of platelets.
E.g. - Von Willebrand disease, ITP, glanzman thromoasthenia, uremia etc.
Causes of ↑thrombin time (TT)
• Afibrinogenemia
• Dysfibrinogenemia
• Heparin administration
A patient on aspirin will have increase in:
A.BTB. CT
C. PT
D. APTT
Ans. A.
Aspirin - It acetylates and inhibits the enzyme cyclooxygenase & TX synthetase - inaätivating them irrevessibly. The platelets are exposed to aspirin in portal circulation before it gets deacetylated in the liver and hence t BT.
Causes of ↑BT- any qualitative or quantitative defect of platelets.
E.g. - Von Willebrand disease, ITP, glanzman thromoasthenia, uremia etc.
Causes of ↑thrombin time (TT)
• Afibrinogenemia
• Dysfibrinogenemia
• Heparin administration
