NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Hemosiderin
C. Hemoglobin
D. Bilirubin
Yellow brown granules were found in liver cells and Kupffer cells of a man with hereditary hemochromatosis. These granules became blue following the Prussian blue reaction. What are these granules?
A. TransferrinB. Hemosiderin
C. Hemoglobin
D. Bilirubin
Ans. B. In hereditary
hemochromatosis, a genetic abnormality of iron absorption in the small
intestine, excess iron is stored mostly in the form of hemosiderin, primarily in the liver, but also in many other
organs. Hemosiderin appears as brown cytoplasmic granules, which turn blue with
the Prussian blue reaction. Transferrin is the plasma protein that transports
iron. Hemoglobin is the red iron-containing pigment of red blood cells. Upon
hemolysis of red blood cells, hemoglobin is degraded into greenish biliverdin
or yellow bilirubin. Bilirubin may accumulate in the liver cells, but it does
not form granules that are Prussian-blue positive.
