NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Ciprofloxacin
C. Piperacillin
D. Cefotaxime
Ans. A. (Streptomycin)
Explanation: Common properties of aminoglycoside antibiotics
• All are used as sulfate salts, which are highly water soIuble solutions are stable for months.
• They ionize in solution; are not absorbed orally; distribute only extracellularly; do not penetrate brain or CSF.
• All are excreted unchanged in urine by glomerular filtration.
• All are bactericidal and more active at alkaline pH. They act by interfering with bacterial protein synthesis.
• All are active primarily against aerobic Gram-negative bacilli and do not inhibit anaerobes.
• There is only partial cross resistance among them,
• They have relatively narrow margin of safety.
• All exhibit ototoxicity and nephrotoxicity.
Which of the following is a nephrotoxic drug?
A. StreptomycinB. Ciprofloxacin
C. Piperacillin
D. Cefotaxime
Ans. A. (Streptomycin)
Explanation: Common properties of aminoglycoside antibiotics
• All are used as sulfate salts, which are highly water soIuble solutions are stable for months.
• They ionize in solution; are not absorbed orally; distribute only extracellularly; do not penetrate brain or CSF.
• All are excreted unchanged in urine by glomerular filtration.
• All are bactericidal and more active at alkaline pH. They act by interfering with bacterial protein synthesis.
• All are active primarily against aerobic Gram-negative bacilli and do not inhibit anaerobes.
• There is only partial cross resistance among them,
• They have relatively narrow margin of safety.
• All exhibit ototoxicity and nephrotoxicity.
