NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Retraction by endothelial venules and capillaries
C. Direct endothelial injury
D. Angiogenesis
Delayed continuous vascular permeability is due to
A. Endothelial contractionB. Retraction by endothelial venules and capillaries
C. Direct endothelial injury
D. Angiogenesis
Ans. C. (Direct endothelial injury)
1. Delayed
prolonged increase in vascular permeability is a curious but relatively
common type of increased vascular permeability that begins after a delay of
2—12 hours, lasts for several hours or even days, and involves venules as well
as capillaries.
2.
Such leakage is caused, for example, by mild to moderate thermal injury, X-Ray
irradiation or ultraviolet radiation, and certain bacterial toxins.
3. Late-appearing sunburn is a good example of a delayed
reaction.
4.
The mechanism of such leakage is unclear. It may result from the direct effect
of the injurious agent leading to delayed endothelial cell damage (perhaps by
apoptosis), or the effect of cytokines causing endothelial retraction, as
described ear-
