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B. Anti-basement membrane disease
C. Alport’s syndrome
D. PSGN
Crescentic GN is seen in all of the following EXCEPT
A. HSPB. Anti-basement membrane disease
C. Alport’s syndrome
D. PSGN
Ans. C. (Alport’s syndrome)
Explanation
Rapidly Progressive (crescentic)
glomerulonephritis is divided into:
• Type I RPGN (Anti-GBMAntibody)
1. Idiopathic
2. Goodpasture syndrome
• Type II RPGN (Immune Complex)
1.
Idiopathic
2. Postinfectious
3. Systemic
lupus erythematosus
4. Henoch-Scholein purpura (IgA)
5. Others
• Type III RPGN (Pauci-Immune)
1. ANCA associated
2.
Idiopathic
3. Wegener granulomatosis
4. Microscopic polyarteritis nodosa
2.
Hereditary nephritis refers to a group of heterogenous familial renal diseases
associated primarily with glomerular injury. Two important ones are: Alport
syndrome and thin basement membrane disease, (the most common cause of
benign familial hematuria).
• Alport syndrome, when fully
developed is manifested by nephritisprogressing
to chronic renal failure, accompanied by nerve deafness and various eye
disorders, including lens dislocation, posterior cataracts and corneal
dystrophy
•
Defective GBM synthesis because of the production of abnormal collagen type IV
(ca-chain in the most common X-linked forms) underlies the renal lesions
