NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Organizing exudates
C. Hyaline membranes
D. Pigmented macrophages
(a) Epithelial cell injury represented by extensive necrosis of type I pneumocytes and a denuded basement membrane,
(b) Swelling of endothelial cells with the widening of intercellular junctions,
(c) The formation of hyaline membranes composed of fibrin and other matrix proteins in alveolar ducts and airspaces, and
(d) A neutrophilic inflammation. Fibrin thrombi may be seen in the alveolar capillaries and smaller pulmonary arteries. The second pathologic phase of ARDS is characterized by proliferation of a variety of cells and resolution of the neutrophilic inflammation. Cuboidal type II cells and squamous epithelium cover denuded alveolar basement membranes. Over the ensuing days to weeks, architectural restoration of lung tissue is usually observed in survivors of ARDS. However, interstitial fibrosis and extensive restructuring of the lung parenchyma may occur with cystic and honeycomb changes in some ARDS patients, resulting in chronic pulmonary dysfunction or death.
The characteristic microscopic finding in acute lung injury is:
A. Intra alveolar fibrinB. Organizing exudates
C. Hyaline membranes
D. Pigmented macrophages
Ans.
C. Hyaline membranes
Features
of ALl (Acute Lung Injury)(a) Epithelial cell injury represented by extensive necrosis of type I pneumocytes and a denuded basement membrane,
(b) Swelling of endothelial cells with the widening of intercellular junctions,
(c) The formation of hyaline membranes composed of fibrin and other matrix proteins in alveolar ducts and airspaces, and
(d) A neutrophilic inflammation. Fibrin thrombi may be seen in the alveolar capillaries and smaller pulmonary arteries. The second pathologic phase of ARDS is characterized by proliferation of a variety of cells and resolution of the neutrophilic inflammation. Cuboidal type II cells and squamous epithelium cover denuded alveolar basement membranes. Over the ensuing days to weeks, architectural restoration of lung tissue is usually observed in survivors of ARDS. However, interstitial fibrosis and extensive restructuring of the lung parenchyma may occur with cystic and honeycomb changes in some ARDS patients, resulting in chronic pulmonary dysfunction or death.
